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Abstract The global contamination of 15% of agricultural soils with toxic metal (loid) species (TMS) including arsenic, cadmium, mercury, and nickel compromises food safety and chronically exposes millions of people to these inorganic pollutants which are absorbed into the bloodstream to various degrees

Potential therapeutic strategies include inhibiting neutrophil NET formation, regulating neutrophil apoptosis pathways, intervening in TLR9-mediated endoplasmic reticulum stress, and targeting gut microbiota and their metabolites

Interestingly, altered intestinal permeability can be exacerbated during IBDs by a variety of external factors, but it has been shown to occur in asymptomatic patients years before the onset of clinical manifestations [99]

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Steroid use may suppress natural testosterone production, alter cholesterol levels, increase blood pressure, affect fertility, and contribute to long-term cardiovascular concerns